More in detail, it was demonstrated that the CXCL-5-CXCR-2 signaling axis was involved in the extravasation process, since gradients of CXCL-5 generated through the microfluidic device were able to attract BCCs to control acellular matrices, while antibodies blocking CXCR-2 significantly reduced BCC transmigration towards bone-mimicking microenvironments. The gene discussed is CXCR2; the disease is skin basal cell carcinoma.