NOTCH3 and neoplasm: The authors performed direct and Transwell co-culture of bone marrow osteoblasts with the human BCCs line MDA-MET (a bone-seeking clone derived from MDA-MB231), demonstrating that both direct contact and secreted factors from osteoblasts induced a two-fold increase in tumor cells of the expression of Notch3, as well as Notch3 ligand Jagged1.