HMOX1 and neuroblastoma: Thus, among wine-phenolic components, ferulic acid exerted neurprotection by increasing HO-1 activity in a human neuroblastoma cell line (116), while resveratrol and epicatechin pretreatment protected against focal cerebral ischemia in rats and mice, respectively, by upregulating expression of Nrf2 and activation of HO-1 to ameliorate oxidative damage (95, 96).