Millon et al. found that mice transplanted with ETV6-ABL1-positive hematopoietic stem cells developed CML-like myeloproliferative disease, and that the TEL pointed homology oligomerization domain was essential to ETV6-ABL1-driven leukemogenesis [15]. This evidence concerns the gene ETV6 and chronic myelogenous leukemia, BCR-ABL1 positive.