Six out of eleven CML patients positive for ETV6-ABL1 reported in the literature were treated with imatinib: three patients showed a transient favorable response followed by relapse, one patient showed significantly decreased levels of leukemic clones, and two patients treated with 400 mg/day during the chronic phase achieved complete remission [1, 6, 18, 20–22]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.