Furthermore, the treatment of Wnt-C59 against bone marrow niche in MMTV-Wnt1-driven mouse mammary tumor models exhibited no toxicity on HSC with no significant effect on complete blood cell count, thus suggesting Wnt secretion can be suppressed using PORCN inhibitor without affecting normal adult hematopoiesis (Kabiri et al., 2015). This evidence concerns the gene PORCN and breast cancer.