AKT3 and malignant colon neoplasm: Moreover, in many other types of cancers, miR-145 and its direct target were also reported, for example, miR-145 directly targets AKT3 in thyroid cancer [10], and miR-145 also targets Mucin 1, cell surface associated in metastatic breast cancer [11], p70S6K1 in colon cancer [12], insulin-like growth factor receptor 1 in human bladder cancer cells [13], c-Myc in non-small cell lung cancer [14] and the transcription factor signal transducer and activator of transcription 1 in colon cancer [15].