PPARA and neoplasm: FA metabolism is deregulated in a number of cancers.5, 9 Specifically, FABPs are involved in tumour biology through their function in regulation of PPAR activity and/or FA uptake and oxidation.3, 4, 10 Interestingly, in FABP4−/− mice, ovarian tumour xenograft growth and metastasis were reduced.11 This was linked to reduced utilization of adipocyte-derived FAs in tumour cells and to reduced FABP4 expression in adipocytes and adjacent tumour cells.11