Although comparable to siRNA depletion of MRE11, MRNIP depletion does not phenocopy the drastic loss of MRN components observed in ATLD, NBS, or NBSLD cells; one might expect that any DDR-related disorder resulting from mutation or loss of MRNIP function would have a much milder phenotype than these severe conditions. Here, MRE11 is linked to ataxia-telangiectasia-like disorder.