However, the data regarding GLP-1RA and glucagon need to be more clarified: recently, in the LIBRA trial it has been demonstrated that long-term treatment with liraglutide in early T2D has been associated with an increased post-challenge glucagonemia [35], while for Albiglutide the evidence is that it does not affect glucagon secretion during hypoglycemia [36]. This evidence concerns the gene GCG and Hypoglycemia.