On the other hand, while an increase of HF has been also reported with sitagliptin use [51], no increase in the incidence of hospitalization for HF was observed with sitagliptin in the trial evaluating cardiovascular outcomes with sitagliptin (TECOS) trial [52, 53], or with incretin therapy in a recent observational study with a large cohort of T2D patients [54]. The gene discussed is GCG; the disease is type 2 diabetes mellitus.