From 1 % to 38 % of the leukocyte population was represented by CD2/CD3/CD5 positive reactive T lymphocytes with a prevalence of CD8 positive cells documented in 13/16 PCNSL cases (81 %) and more than 40 % of CD56 positive T cells in two (Table 2, cases n°1 and n°14). The gene discussed is CD8A; the disease is primary central nervous system lymphoma.