We found that stage (P = 0.050), tumour status (P = 0.001), DNASE1L3 expression (P = 0.042), and INTS8 expression (P = 0.023) were independent risk prognostic factors for OS in HCC patients, although no gene was found to be an independent prognostic factor for DFS (data not shown). The gene discussed is DNASE1L3; the disease is hepatocellular carcinoma.