In this study, we found that, potentially regulated by demethylation (Fig. 7), INTS8 was significantly and consistently upregulated at least 2.115-fold in HCC according to four independent microarrays (Fig. 1; Table 1) and that INTS8 mRNA was upregulated 2.06-fold on average in 11 tissues of HCC patients compared with corresponding paracancerous tissues, with a similar expression profile at the protein level (Fig. 2). The gene discussed is INTS8; the disease is hepatocellular carcinoma.