As shown in Fig. 2a, the expression of TBCE and INTS8 was increased, whereas that of VIPR1, CLEC4M, MARCO, DNASE1L3, CRHBP, and FCN2 was decreased in HCC tissues, although the changes in TBCE and VIPR1 expression were not statistically significant. This evidence concerns the gene CRHBP and hepatocellular carcinoma.