Positivity for cleaved caspase-8 was detected in the ischemic core and the peri-infarct area (Fig. 1a) and could be associated with the Iba1-positive cells, as illustrated with immunofluorescence double staining confirming expression of cleaved caspase-8 in Iba1-positive cells upon stroke (Fig. 1b). Here, CASP8 is linked to stroke disorder.