As seen in Figure 5D, the nuclear expression of β-catenin was significantly increased in Group 2, whereas its expression in Group 4 was significantly changed compared to those seen in Group 2 (P < 0.001), suggesting that inhibition of β-catenin translocation from cytoplasm to nucleus might explain the anti-cancer effects in fat-1 TG mice, similar to findings in in vitro documentation that DHA significantly regulated β-catenin activation (Figure 1D). Here, FAT1 is linked to cancer.