Among the aforementioned diverse reports describing models for cancer prevention by ω-3 PUFAs, only three publications on the pancreatic ductal adenocarcinoma model containing p48Cre/+−LSL-KrasG12D/+ [7], the colon adenoma model containing APCmin/+ [15], and the breast cancer model describing down-regulation of the transmembrane tyrosine kinase receptor HER2 pathway [8], showed specific mechanisms explaining cancer prevention by ω-3 PUFAs in fat-1 TG mice. The gene discussed is FAT1; the disease is breast carcinoma.