FAT1 and cancer: The fat-1 transgenic (TG) mice [1] and fat-1 TG cattle [2] were designed to convert ω-6 to ω-3 polyunsaturated fatty acids (PUFAs) through transgenic expression of n-3 desaturase enzyme and have been acknowledged as an ideal model to study the effect of endogenous ω-3 PUFAs on various diseases, from benign metabolic and inflammatory diseases to several kinds of cancer.