After the introduction of fat-1 TG mice by Kang et al. [4], numerous publications documented the cancer preventive effects of ω-3 PUFAs against diverse cancer models such as lung cancer [5], melanoma [6], pancreatic cancer [7], breast cancer [8], prostate cancer [9], liver tumor [10, 11], colorectal cancer, and colitic associated cancer (CAC) [12–14]. Here, FAT1 is linked to melanoma.