In a Scandinavian study, the prognostic role of the NR1I2 gene variants were examined in primary sclerosing cholangitis; none of the NR1I2 variants were a predisposing factor to the disease, but patients with the rs3814058 homozygous variant genotype had a lower median survival [30]. This evidence concerns the gene NR1I2 and sclerosing cholangitis.