For example, employing proteomic analysis on conditional GEMMs for BRCA1-deficient and -proficient breast tumors, we have previously identified a tissue-specific signature of 45 proteins, that can discriminate human BRCA1- and BRCA2-deficient breast carcinomas from other familial or sporadic breast carcinomas [8–10]. Here, BRCA2 is linked to breast carcinoma.