Eleven other genes identified (GFRA1 [22], SLITRK1 [23], KCNQ1 [24], MEST [25], FRZB [26], GALR1 [7], PMEPA1 [27], RARRES2 [28], GSTM2 [29], TNFRSF8 [30], TUSC3 [31]) have been previously reported as genes with aberrant methylation in other forms of cancer. The gene discussed is MEST; the disease is cancer.