In combination with the findings of the cross-validation results and the TCGA dataset for colorectal carcinoma (CRC) and the ROC curves which showed that GFRA1 and GSTM2 had a greater AUC than SEPT9, this study supports the possible role for these two genes as potential diagnostic molecular biomarkers for CRC. The gene discussed is GSTM2; the disease is colorectal carcinoma.