Ten of the 36 (EYA4 [14], FOXI2 [15], CNRIP1 [16], SFRP1 [17], ADHFE1 [18], C2orf40 [19], MAL [20], PHACTR3 [21], SST [20], TMEFF2 [15]) were known as rectal cancer related genes with aberrant methylation. The gene discussed is EYA4; the disease is rectal cancer.