We observed, however, a strain dependent effect of Cdh1 with both ApcMin/+ (129Ola) and Apcfl/+(B6D2)Vil-CreERT2, as the differences in adenoma counts and survival between either ApcMin/+ or Apcfl/+ diminished when the alleles were back-crossed from a mixed background to C57BL/6J, consistent with the presence of non- C57BL/6J modifier alleles [31]. The gene discussed is VIL1; the disease is adenoma.