CDH1 and adenoma: Surprisingly, conditional generation of intestinal adenoma following tamoxifen administration in Apcfl/flCdh1fl/flLgr5CreERT2 did not result in frequent and detectable recombined Cdh1Δ/Δ alleles, yet subsequent adenoma organoid cell culture manipulated using adenovirus Cre vectors, induced recombination of Cdh1 alleles.