Of the surviving cohort of Cdh1fl/flVil-CreERT2 treated with low dose tamoxifen and aged to one year, neither adenoma nor tumors formed (Cdh1fl/flVil-CreERT2 n=4, Cdh1+/flVil-CreERT2 n=6, Cdh1+/+Vil-CreERT2 n=3). Here, VIL1 is linked to adenoma.