A recurrent and specific gain of chromosome arm 3q was detected in 12 out of 13 (92%) of IPMN with complex Karyotype (Figure 2B), encompassing known oncogenes classified in Cancer Gene Census, such as PIK3CA, GATA2 and TERC, thus possibly linked to the deregulation of cell growth and to the progression of disease. Here, PIK3CA is linked to cancer.