The mRNA expression of PIK3CA, GATA2 and TERC, the candidate oncogenes on chr 3q, were evaluated by qRT-PCR in IPMN with normal karyotype and IPMN with gain of 3q, and the results were compared to normal pancreatic tissue (Figure 5). Here, PIK3CA is linked to pancreatic intraductal papillary-mucinous neoplasm.