Thrombin is regarded as a key mediator in cancer growth and metastatic spread, via both the formation of fibrin and via its plethora of PAR-1 mediated cellular responses, including effects on DNA synthesis and cell proliferation, platelet activation, vascular permeability, cell migration, and induction of pro-angiogenic and pro-metastatic factors, such as VEGF (Reviewed in [38]). Here, F2R is linked to cancer.