Effect of CGS-21680 (100 nM and 1 μM) and SCH 442416 (1 μM) in cultured lymphocytes of patients with systemic lupus erythematosus (SLE) (n = 20) and healthy subjects (n = 20) stimulated by lipopolysaccharide (LPS) (0.1 mg/ml) or phorbol 12-myristate 13-acetate (PMA) (2 ng/ml) and ionomycin (0.2 μM) on (a) IL-2 release, (b) IL-10 release, and (c) NF-kB activation. This evidence concerns the gene NFKB1 and systemic lupus erythematosus.