To investigate the potential anti-inflammatory role of A2AAR stimulation in SLE, we evaluated the effect of CGS-21680 on the release of some of the most relevant proinflammatory cytokines involved in the pathogenesis of SLE, such as IFN-α, TNF-α, IL-6, IL-1β, and IL-2. Here, IL6 is linked to systemic lupus erythematosus.