As shown in Fig. 4c and e, breast cancers with higher FOXP3+ TIL level were positively correlated with c-erbB-2 status(pooled RR:1.52, 95 % CI:1.32–1.75; P < 0.05), lymph node status(pooled RR:1.17, 95 % CI:1.04–1.32; P < 0.05). The gene discussed is FOXP3; the disease is breast cancer.