In the case of HBV-associated HCC, specific siRNAs were designed against splicing factors U2AF2, SF3A2, RBM8A, RBM4, PRPF4B, NOVA1, KHSRP, HNRPU, HNRPL, HNRPH1, HNRPC, and HNRPA1. This evidence concerns the gene HNRNPU and hepatocellular carcinoma.