The MET-EMT cycle, along with differences between primary HCC and metastatic HCC, might also explain why no significant evidence for gene over-expression of traditional mesenchymal markers (such as vimentin or N-cadherin) or repression of epithelial ones (e.g., E-cadherin) was found in tissues from HCC patients in the TCGA database. Here, CDH1 is linked to hepatocellular carcinoma.