MDM2 and neoplasm: Other examples of aberrantly-spliced genes detected in HCC include the serine/threonine kinase aurora kinase B (AURKB), the E3 ubiquitin ligase, the p53-antagonistic protein MDM2, the cell surface adhesion cadherin 17 protein, and the Hugl-1, Klf6, and p73 tumor suppressors [11].