In the case of HBV-associated HCC, specific siRNAs were designed against splicing factors U2AF2, SF3A2, RBM8A, RBM4, PRPF4B, NOVA1, KHSRP, HNRPU, HNRPL, HNRPH1, HNRPC, and HNRPA1. Here, PRP4K is linked to hepatocellular carcinoma.