Recent studies have also shown that TSG reduces the overexpression of amyloid precursor protein (APP) [14], inhibits reactive oxygen species generation [15], and attenuates cognitive impairment in several animal models of AD, including age-advanced rats [11], APP transgenic mice [16], amyloid-β1–42-injected rats [12], and aluminium-exposed rats [14]. This evidence concerns the gene APP and Cognitive impairment.