Memory scores (CAMCOGmemory) only appeared to be associated with the cholinergic pattern which is not unexpected given the observed deficits to spatial networks involving the medial temporal lobe structures, and the putative role of acetylcholine on learning and memory (Hasselmo, 2006, McGaughy et al., 2000), as well as the established therapeutic efficacy of cholinesterase inhibitors in ameliorating cognitive symptoms in AD (Zemek et al., 2014). This evidence concerns the gene BCHE and Alzheimer disease.