As the most commonly seen member of the histone deacetylase family, HDAC6 is mainly distributed in the cytoplasm and regulates cellular morphology, adhesion, and migration with α-tubulin, HSP90 and cortical actin as the substrates [19], while the cellular migration is a prerequisite of many physiological processes, such as exudation of leukocytes during inflammation, metastasis of cancer cells, wound healing [20, 21]. The gene discussed is HDAC6; the disease is cancer.