GPT and Pleural effusion: A previous systematic review and meta-analysis showed that several clinical factors, including age, female sex, neurological signs, nausea/vomiting, abdominal pain, gastrointestinal bleeding, hemoconcentration, ascites, pleural effusion, hypoalbuminemia, hypoproteinemia, hepatomegaly, high levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), abnormal coagulators, primary/secondary infection, and DENV-2, were independently associated with the development of dengue shock [13].