SOD1 and amyotrophic lateral sclerosis: Mutations in genes such as superoxide dismutase 1 (SOD1) [4], TAR DNA-Binding Protein (TDP 43) [5], fused in sarcoma (FUS) [6], Ubiquilin2 (UBQLN2) [7], and C9ORF72 [8,9] are implicated in genetic causes of ALS.