Complement factor D (CFD), which is a serine protease required for the generation of the C3 convertase, is currently a focus of interest due to on-going clinical trials of the function-blocking antibody Lampalizumab in dry AMD [13,14], and Cfd gene knockout has been shown to be protective in a mouse model of light-induced phototoxicity [15]. This evidence concerns the gene CFD and dry age related macular degeneration.