Quantification of the plaque areas (median/interquartile range) of the aortic sinus after 24 weeks on the WTD, however, revealed that C-Ldlr-/- Rag1-/- (55916/53488 μm2) and C-Ldlr-/- Rag1-/- Il2rg-/- (44522/34736 μm2) immunodeficent mice developed significantly more atherosclerosis compared to C-Ldlr-/- controls (25285/24975 μm2, p<0,01, Fig 2A, right panel). The gene discussed is IL2RG; the disease is atherosclerosis.