For example, if there was a clinical stage T2b nodule on 1 side, the serum PSA was 20 ng/ml, the biopsy Gleason sum was 7 (4+3), the percentage of positive cores 50%, the maximum cancer percentage was 40%, and the ECE risk score was 3, the probability of ECE by the third model would be 70% for this single lobe. The gene discussed is KLK3; the disease is cancer.