Our previous studies showed that DRE treatment rapidly and efficiently activates the extrinsic pathway of apoptosis in leukemia, melanoma and pancreatic cancer cells and this process is dependent on the activation of caspase-8 as the cells with a dominant-negative Fas-Associated Death Domain (Dn-FADD) are unresponsive to the DRE treatment [12]. The gene discussed is CASP8; the disease is melanoma.