CASP8 and colorectal cancer: The results showed that cytotoxicity occurred even in the presence of the caspase-8 inhibitor, IETD-fmk, and the corresponding loss of HT-29 cells' viability in response to the DRE treatment was dose and time dependent (Figure 6D), suggesting that in HT-29 colorectal cancer cells the DRE-induced cell death was caspase-8 independent.