MYCN and neuroblastoma: To explore the anti-tumor effect of ponatinib on NB cell lines, three MYCN-amplified cell lines (IMR-32, NGP and NB-19) and three MYCN-non-amplified cell lines (SH-SY5Y, SK-N-AS and LA-N-6) were exposed to increasing concentrations of ponatinib for 72 hrs.