More importantly, in a TMA containing 33 cases of glioma samples (duplicates, N=66), 2 anaplastic astrocytoma (duplicates, N=4), 11/59 GBM spots showed moderate Btk staining and 35/59 showed strong staining, suggesting 77.9% of the GBM samples stained for Btk (Table 2). The gene discussed is BTK; the disease is central nervous system cancer.