To evaluate the potential relevance of the above findings in ESCC in clinical practice, we also analyzed the protein expressions of p-mTOR and t-mTOR in tissues from 152 human ESCC patients using immunohistochemistry, and there was a significant correlation between AT1R expression and p-mTOR expression (P<0.001, Table 2). The gene discussed is AGTR1; the disease is esophageal squamous cell carcinoma.