It was found that K562, a BCR-ABL positive CML line, was highly sensitive to Bisindolylmaleimide IX (Figure 3A), compared to HL-60 (BCR-ABL negative leukemic line), breast cancer cell line MCF7, glioma cell line U251, gastric cancer cell lines AGS and MGC-803, osteosarcoma cell lines U2OS and Saos-2 (Figure 3B-3G). Here, ABL1 is linked to osteosarcoma.