HMGB1 and coronary artery disorder: Serum HMGB1 (192.8 ± 33.24 pg/mL) and IL-6 (91.7 ± 13.5 pg/mL) levels in human CAD patients were significantly higher than those in the control subjects (HGB1: 2.5 ± 33.24 pg/mL; IL-6: 26.7 ± 6.42 pg/mL) (Figure 7A,B).