Hypoadiponectinemia, a typical trait of NAFLD, suggests that adiponectin, as an antagonist of tumor necrosis factor α (TNF-α), has anti-lipogenic and anti-inflammatory effects that can protect the liver from damage by maintaining the balance between pro-inflammatory and anti-inflammatory cytokines in hepatocytes [34]. This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.