Furthermore, the serum adiponectin concentration coupled with the waist-to-hip ratio and AST/ALT ratio could serve as a novel tool with which to diagnose advanced fibrosis of NAFLD, suggesting that increasing adiponectin levels may be a new therapeutic method for inflammation and fibrosis in patients with NAFLD [35]. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatotic liver disease.