TRIB2 has previously been shown to function as an adaptor mediating the degradation of C/EBPα via COP1 E3 ligase in AML [39] or TRIM21 E3 ligase in lung cancer [14], and these are likely candidates that link the TRIB2 pseudokinase domain to ubiquitination. This evidence concerns the gene CEBPA and acute myeloid leukemia.