KRAS and adenoma: Frequent mutations of KRAS (36-44%) [20, 21] and TP53 (31-40%) [22, 23] were reportedly involved in FAP cancer, while mutation frequencies of those in adenomas are rather low, 6-36% for KRAS [20, 24, 25] and 5-38% for TP53 [22, 23, 26].