Wynter et al. analyzed eight methylation markers (MINT1, MINT2, MINT12, and MINT31 markers, and promoter regions of HPP1, MGMT, p14, and p16) in sporadic and FAP adenoma samples and suggested that FAP adenoma might develop through non-CIMP pathway [24]. This evidence concerns the gene TMEFF2 and Familial adenomatous polyposis.