The first observations of the efficacy of NF-κB targeting strategies come from CML and Ph+ ALL cellular models and were obtained with BAY11-67082, an inhibitor of the IκB-α phosphorylation [66], and Bortezomib (PS-341), which blocks proteasome-mediated IκB-α degradation [85-87]. This evidence concerns the gene NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive.