DNMT3A and B-cell chronic lymphocytic leukemia: The first report demonstrating that Dnmt3a plays a tumor suppressive role in the prevention of hematologic malignancy was published by Peters et al. (8), which showed that conditional inactivation of Dnmt3a in HSPCs using EμSRα-tTA;Teto-Cre;Dnmt3afl/fl;Rosa26 LOXPEGFP/EGFP quadruple transgenic mice (designated as Dnmt3aΔ/Δ mice) results unexpectedly in the development of a CLL-like disease after 1 year’s time.