In addition, Dnmt3a loss can collaborate with gain of function mutant c-kitD814V to induce B-ALL, T-ALL, and mastocytosis with myeloid blasts (17), and with KrasG12D/+ to promote progression of juvenile and chronic myelomonocytic leukemia (CMML) (19). Here, DNMT3A is linked to chronic myelomonocytic leukemia.