AKT1 and heart valve disorder: Our data are in contrast to findings by Chang et al. who demonstrated that low-dose simvastatin treatment with 20 mg per day even for the short period of 5–7 days in patients with valvular heart disease was sufficient to induce HDL-mediated phosphorylation of Akt and eNOS at Ser1177 and to inhibit eNOS phosphorylation at the Thr495 site in cultured human umbilical vein endothelial cells, resulting in enhanced NO production.