CRP and chronic obstructive pulmonary disease: During the RW and COPD periods, the CRP and SAA levels in MXF+STL/NS group were significantly reduced compared with TSG/NS group on Day 10 and Day 6 (P < 0.05), and they were significantly reduced in the 2 sequential treatment groups, TSG/BYG and MXF+STL/STL, compared with TSG/NS group and MXF+STL/NS groups from Day 12–Day 22, respectively.