Alternatively, another group in China recently reported that the activation of PPAR-γ by troglitazone inhibited HMGB1 protein expression through upregulation of microRNA- (miRNA-) 142-3p in THP-1 cells, a human monocytic cell line derived from an acute monocytic leukemia patient, and in murine peripheral blood mononuclear cells isolated from model mice blood [42]. The gene discussed is PPARG; the disease is acute monocytic leukemia.