A multivariate Cox regression analysis of the factors associated with CKD progression further indicated that this intermediate level of the ADCC responsiveness observed in KTRs (CD107a/Lamp1URI > 3) was associated with the occurrence of graft function decline (≥10% eGFR loss) or graft failure in 34% of the transplanted recipients during the mean follow-up period of 13.3 months (Figure 2C and Table 2). Here, LAMP1 is linked to chronic kidney disease.