On the molecular side various factors also relevant for the development of hypertension in nonpregnant individuals show alterations in PE patients: antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1, also known as sVEGFR1) is a naturally occurring, circulating antagonist to vascular endothelial growth factor (VEGF). Here, VEGFA is linked to hypertensive disorder.