DES and neoplasm: Four cases of sclerosing RMS also displayed focal areas of tumor with spindle cells, as noted earlier.8, 10, 11, 12 Whereas fascicular pattern was the most commonly observed tumor pattern in cases of spindle cell RMS, pseudovascular pattern was most commonly observed in cases of sclerosing RMS.4, 5, 7, 8, 9, 10, 11 By immunohistochemistry, all 21 cases displayed desmin positivity, along with MyoD1 positivity in 90% cases and myogenin positivity in 90% cases.