In line with the comparison between liver fibrosis stages 0–2 and 3–4, the higher SK1, SPNS2, and S1P2 mRNA levels were noted in the patients with fibrosis stages 3–4 compared to the patients with normal liver, though not statistically significant due to the relatively small number of patients with normal liver. The gene discussed is S1PR2; the disease is Hepatic fibrosis.