HAND2 and cancer: Indeed, broadly speaking, there were three types of silenced TFs in each cancer type (Fig. 5b): those predominantly exhibiting promoter hypermethylation but with relatively few CNV losses (e.g. FOXF1 in LUAD, HAND2 in COAD), those exhibiting frequent CNV loss but not many DNAm changes (e.g. NR2F1 in LSCC, FOXO3 in LUAD, SETBP1 in COAD) and a third class of TFs which exhibited both CNV loss and promoter hypermethylation (e.g. ZNF132 in LUAD, HIC1 in COAD).