In the present study, we prepared a virus-like particle (VLP) CTGF vaccine by inserting a CTGF-derived polypeptide (aa 138–159) into the major immunodominant region (MIR) of the C-terminus truncated hepatitis B virus core antigen (HBc), tested its antigenicity and verified its protective effect in CCl4-induced hepatic fibrosis in BALB/c mice. This evidence concerns the gene CCN2 and Hepatic fibrosis.