In a mouse model of traumatic brain injury, a single dose of telmisartan given 6 h after injury caused reduced perilesional staining for CD68, ionized calcium binding adaptor molecule 1 (Iba-1), and myeloperoxidase (MPO) at 72 h, while a similar treatment 24 h after injury had no such effect [52]. The gene discussed is MPO; the disease is injury.